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Lipid peroxidation is a free radical chain reaction, mediated by lipoxygenases such as arachidonate 15-lipoxygenase, which recognizes the double-bond sites of PUFAs in membrane phospholipids and converts them into lipid hydroperoxides [57, 61]

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Topical isotretinoin continues to support cell turnover in this phase alongside tranexamic acid for hyperpigmentation and niacinamide (vitamin B3) for barrier support and redness reduction