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doi: 10.1113/jphysiol.2012.247171, 91 RajabA

Prognostic and therapeutic relevance of the IGF pathway in Ewings sarcoma patients

It protects collagen and elastin from degradation as well as boosts their production
The macrophages increase in number and may come to comprise the cuff, appearing as discrete granulomas, which, depending on the plane of section, may appear to be in the parenchyma
