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Zinc depletion with prolonged supplementation 2

Oxidative stress causes membrane lipid peroxidation, impairs mitochondrial function and decreases antioxidant enzymatic activity, all together leading to liver damage (51)

Pharmacological stabilization of HIF-1 has been shown to induce expression of the vitamin D receptor and antimicrobial peptide hBD-2, while simultaneously reducing the release of TNF- and IL-10, thereby significantly inhibiting bacterial proliferation (Nickel et al., 2012)

doi: 10.3390/foods10091991, 113
