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A single intranasal application of Semax at 50 mcg/kg body weight produces a 1.4-fold increase in BDNF protein levels in the rat hippocampus, accompanied by a 1.6-fold increase in TrkB tyrosine phosphorylation and a 3-fold increase in exon III BDNF mRNA levels

[52] In humans, the projection of dopaminergic neurons from the substantia nigra pars compacta to the dorsal striatum, termed the nigrostriatal pathway , plays a significant role in the control of motor function and in learning new motor skills