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of tauopathies is defined as intracellular accumulation of neurofibrillary tangles (NFTs) consisting of aggregated hyper- and abnormal phosphorylation of tau protein and neuroinflammation

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In 2009, a number of studies showed that the GPx-4 overexpression strongly protected the retina from oxidative damage-induced retinal degeneration (83)

If the cellular clearance rate of misfolded SOD1 is inadequate, increasingly frequent hydrophobic interactions ultimately give way to aggregation, forming larger amorphous structures that stress the cellular machinery 21