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Researchers have established that lower GABA levels correlate with increased axon firing and energy needs in the sensorimotor cortex and hippocampus, perhaps leading to neuroaxonal degeneration in patients with MS with advanced disease [20]

Hydrophobic or charged hydrophilic molecules diffuse poorly through mucus, while uncharged hydrophilic molecules can move quickly through the mucin mesh, with smaller molecules moving almost as fast as water

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The question is how confidently those effects translate to humans at the doses being used, through the delivery routes being used, over the time periods being used