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encoded by the SLC6A6 gene) is a sodium and chloride ion-dependent transporter ubiquitously expressed in mammalian tissues

A., Sakatani, T., Sugamura, K., Makino, M., Ito, H., Savaraj, N., Kaibara, N., and Kuo, M

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In vitro studies underpinning the design of the helix-B-derived peptides have documented that the pyroglutamate helix-B surface peptide (the structure corresponding to ARA-290) retains anti-apoptotic, cytoprotective activity, while lacking erythropoietic activity, and have attributed this cytoprotection to signalling through the EPO receptor (EPOR)/beta-common-receptor heterocomplex rather than the classical erythropoietic EPOR [1]