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Annalou G

W., Jiang F., Chen Y., Yamamoto K

This suggests that the beneficial effects of metformin may be due to the strengthening of the intestinal mucosal barrier (de la Cuesta-Zuluaga et al., 2017)

The metabolic change affects the balance of pro-inflammatory and anti-inflammatory cytokines and other immune factors, promoting the decline of the gut epithelial barrier