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The combination of anti-angiogenic drugs and chemotherapy drug docetaxel can effectively inhibit the synthesis of mitochondrial DNA in hypoxic tumor stem cells, thereby improving the efficacy of anti-angiogenic drugs (187)

PMID: 27365650

For instance, MMP2 overexpressing tumor microenvironment has been exploited by Naz and colleagues to develop nanoparticles functionalized with PVA peptides (PPCs) [351]

To examine the influx of immune cells, histopathological analysis was performed on lumbar spinal cord sections of mice, either or not immunized with spinal cord homogenate, by labeling for Mac-3 + macrophages, B220 + B cells, and CD3 + T cells