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Immune cells use ROS to sustain their functions and need adequate levels of antioxidant defenses to avoid harmful effects caused by excessive ROS production, since accurate balance between ROS and intracellular antioxidants is essential for a normal function of the cell (Banjac et al., 2008

The full cascade of benefits from optimized GH levels takes time to manifest because cellular repair and metabolic adjustments accumulate gradually
Leong F, Hua X, Wang M, Chen TK, Song YL, Tu PF, et al

Strategies for vascularized skin models in vitro[J]