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D-Retro-Inverso Stability The D-retro-inverso modification gives FOXO4-DRI exceptional stability against proteolytic degradation while preserving the three-dimensional structure needed for FOXO4 interaction

If we observe the structure we can find a steroid nucleus with 21 carbons extended with an ester group forming the lactone ring

By simultaneously eliminating senescent cells and modulating the harmful effects of their secretory phenotype, combination therapies hold the potential to address the multifaceted nature of aging and age-related diseases.39,119 This integrated approach offers a comprehensive strategy for improving healthspan, reducing chronic inflammation, and enhancing tissue regeneration