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Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]

The buccal mucosa is a key site for drug delivery, offering high permeability and dense vascularization that supports rapid molecular diffusion and absorption into the systemic circulation [37,38]

Contains no more than 57 mcg/L of aluminum

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