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This model is supported by evidence from various experimental systems, including the ability of lactate to sustain synaptic function in vitro (Schurr et al., 1988), the cellular localization of relevant transporters and enzymes, and in vivo studies using microsensors that report rapid lactate consumption coupled to oxygen utilization in the tissue parenchyma during activation (Hu and Wilson, 1997)

Identificationof aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by PGA 1 : implications for anti-tumoral activity

[DOI] [PubMed] [Google Scholar] 108.Libiad M., Motl N., Akey D.L., Sakamoto N., Fearon E.R., Smith J.L., Banerjee R

Growing evidence indicates that dysbiosis, immune activation, and IEB dysfunction have a role in several diseases, including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gluten-related conditions