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Research demonstrates that copper-binding peptides including GHK-Cu suppress the NF-B pathway through direct molecular interactions, with nuclear translocation of NF-B p65 decreased by approximately 30% upon treatment and molecular modeling showing specific peptide sequences exhibit high binding affinity to NF-B p65 (up to -8.8 kcal/mol)

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I. Schelleret al., Thymosin 4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets, Ferrata Storti Foundation (Haematologica), Aug. 2021. doi: 10.3324/haematol.2021.278537