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When you do not have enough GSH to fight against free radicals, the resulting oxidative stress may lead to diseases like diabetes, rheumatoid arthritis, and Alzheimers disease
The isotopic doublets derived from GSH and 13 C 15 2 N-GSH should differ by three mass unit and show a peak intensity ratio around 1:1

Gastroenterology 144 , 789798 (2013)

Therefore, p62 protein expression is negatively correlated with autophagic activity
