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J Peripheral Nerv Syst JPNS

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bone fracture, osteoporosis, and rheumatic arthritis), low back pain, traumatic hematoma, uterine bleeding and those caused by the deficiency of the liver and kidney (Figure 1A (M0)), also known as Asperosaponin VI, is a main bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall ( FIGURE 1 Although ASD has a variety of biological activities and a great potential for medicine, the research on the pharmacological mechanism and the development of new drugs involving ASD has been somehow hampered by the incomplete metabolite spectrum in vivo and the ultra low absolute oral bioavailability ( O -- L -arabinopyranosyl hederagenin and hederagenin (Figure 1A (M1M5)) ( in vivo after oral administration, we speculated that 1) the pharmacological effects of ASD may be derived from parent drugs and metabolites, intermediate or final