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For those seeking non-invasive BDNF enhancement, the evidence supports high-intensity interval training (HIIT)12 weeks of HIIT produced 20% increases in hippocampal BDNF and improved cognitive flexibility in older adultsand flavonoid-rich diets containing polyphenols from sources like green tea and dark chocolate

Interestingly, excessive ROS production and oxidative stress raises the binding affinity of the spike protein for the human ACE2 receptor (Hati and Bhattacharyya, 2020