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Functionally, it facilitates the transport of long-chain fatty acids into mitochondria for -oxidation while also donating propionyl groups that enter the Krebs cycle, thereby supporting both aerobic energy production and vasodilation through increased nitric oxide synthesis

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While the activity of NHR-49 is regulated at multiple levels including cofactor interactions, heterodimerization with other nuclear receptors, and isoform-specific subcellular localization 23,42,45,46,47,48 , nuclear hormone receptors are classically defined as ligand-regulated transcription factors 49,50,51,52,53