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Conclusions Metabolic neuroimaging has revealed important insights into the pathophysiology of ME/CFS and Long-COVID, identifying shared features such as glucose hypometabolism and elevated Glu, as well as distinct features in oxygen extraction

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Experimental studies have shown that dietary supplementation with ketone esters or low-percentage fat enrichment can restore locomotor rhythmicity, normalize expression of SIRT1 and core clock genes, and ameliorate neurodegeneration [53]

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