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It directly drives lung cancer progression through multi-dimensional independent mechanisms and acts as a key synergistic factor to amplify the pro-carcinogenic effects of CIH, with core regulation focusing on immune microenvironment remodeling, oxidative stress, intercellular communication, and neuro-inflammatory crosstalk (Gozal et al., 2015)

doi: 10.16693/j.cnki.1671-9646(X).2017.10.047 39

Considering the results of the previous studies, it is possible to outline a hypothesis about the involvement of cannabinoids in the HPA axis and subsequent regulation of the P450 enzymes (see Figure 1 below)

Epigenetic mechanisms in heart development and disease