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During the acute phase, elevated dopamine levels disrupt motor coordination, resulting in psychomotor agitation and involuntary movements

Berger MM, Pantet O, Schneider A, et al

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On the other hand, a primary defect in energy metabolism (mitochondrial disease, genetic component being in a gene involved in energy metabolism) will result in delayed homeostasis of the ion gradient in active neurons and their associated glia due to under function of the ATP-dependent cation pumps