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The precise mechanism through which HMGB1 induces EMT in asthma remains unclear, but it may potentially involve RAGE and the phosphatidylinositol 3 -kinase/Akt/glycogen synthase kinase 3/-catenin (PI3K/Akt/GSK3/-catenin) signaling pathway (92) or the RAGE/NF-B signaling pathway (93)
ClinicalTrials.gov (2026) 11
Y., Wu, Y
Metallomics 5:11461169 Li G, Meng X, Wang R, Mao G, Han L, Liu Y et al (2012) Dual level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis
