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Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways

This series of pathological alterations further exacerbates local hypoxia and, through the classic hypoxia signaling pathway, stabilizes HIF-1, thereby driving disease progression [102]

Gain-of-function mutations in oncogenes (such as RAS superfamily) or positive regulators (such as NF-B inducing kinase) contribute to sustained activation of NF-B signaling and subsequent cell proliferation
consists two distinct genes coding for different SOD such as FeSOD-1 and FeSOD-2 [40]
