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(1) The researchers performed docking simulations and suggested that the tripeptide may form stable binding poses with VEGFR-2 through multiple hydrogen bonds, including interactions with residues such as LEU-37, LYS-117, CYS-116, and ASN-120

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

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