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Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Kozlov S.V., Waardenberg A.J., Engholm-Keller K., Arthur J.W., Graham M.E., Lavin M

JCI Insight 9, (2024), Application(s): WB, Abstract DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy: Kumar, R., Khan, M., et al

Anatol J Cardiol
