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10.1038/ng1098 14
Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles
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The early activation of ion channels, kinase cascades, and PTMs indicates that stress signaling operates through a multilayered regulatory system capable of adjusting metabolism, gene expression, and protein stability within seconds to minutes of exposure
