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3.7 Coagulation and other pathways activated in CHL We observed a significant upregulation of proteins in CHL compared to polyp, specifically those involved in blood coagulation and fibrin clot formation ( p adjusted = 7.1E-08, GO_BP), formation of fibrin clot (clotting cascade) ( p adjusted = 4.5E-07, REAC), common pathway of fibrin clot formation ( p adjusted = 2.9E-05, REAC), and blood clotting cascade ( p adjusted = 0.0001, WP) (Supplementary Table S6

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