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Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

Abdallah CG, Sanacora G, Duman RS, Krystal JH

In studies of human glioblastoma, the absence of exogenous Gln significantly reduces glutamate levels, resulting in the conversion of the dimer GLS1 into a self-assembled, extremely low Km filamentous polymer that further depletes intracellular Gln

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome