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The animals were treated ethically according to the strict guidelines for the care and use of laboratory animals

These mitochondrial morphological alterationsincluding reduced organelle size, increased membrane density, and cristae disruptionare established ultrastructural hallmarks of ferroptosis and are functionally associated with impaired mitochondrial bioenergetics, including loss of membrane potential, diminished electron transport chain activity, and excessive ROS generation (Figure 2G)

Theaflavins successfully mitigated the negative impact of elevated iron levels on serum iron and erythropoiesis

J Intern Med 282:284297