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Due to insufficient blood supply, rapidly growing tumors in vivo are often hypoxic, and it is conceivable that this could enhance the therapeutic efficacy of APR-246, both in wild type and mutant TP53-carrying tumors
doi: 10.1111/j.1476-5829.2009.00197.x
Left untreated, a severe deficiency can cause permanent nerve damage
doi: 10.1210/mend.15.11.0725 [DOI] [PubMed] [Google Scholar] 94
