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Description
Upon activation, JAK2 phosphorylates STAT3, leading to STAT3 dimerization, translocation to the nucleus, and binding to target gene promoters
In this way, NRF2 drives the expression of various enzymes and signaling proteins involved in drug metabolism, antioxidant defense, and oxidative signaling, playing a crucial role in managing cellular responses to oxidative stress [7]
Mechanism and antidote [edit] NAPQI becomes toxic when GSH (glutathione) is depleted by an overdose of acetaminophen
HR, Hormone receptor
