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Persistent Nrf2 signaling has been associated with enhanced proliferation, metastatic dissemination, and resistance to multiple chemotherapeutic agents

3.5 CB-839 induces autophagy in CLL cell lines Because glutamine flux regulates mammalian target of rapamycin complex 1s kinase activity, which is responsible for autophagy, we assessed the effects of glutaminase inhibition on autophagy as an alternative mechanism of CB-839mediated cell death (3235)

Research must focus on intelligent, stimuli-responsive, biomimetic, and potentially multifunctional (theranostic) nanoplatforms with rigorous safety evaluation

10.3390/ijms20133129 156 YeX.ChenX