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Afamelanotide is a treatment for a rare condition called erythropoietic protoporphyria which causes severe pain on sun exposure

In mammals, spermatogenesis is primarily regulated by Sertoli cells which play an essential role in supporting and nurturing the survival, proliferation, and differentiation of germ cells [5]

In addition, cytoplasmic NAD+ is generated by NADH-electron transfer to pyruvate, reducing it to lactate (the Warburg effect)

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