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On the other hand, CTBs strong binding affinity for the ganglioside GM1, which is ubiquitously expressed on most mammalian cell types, improves uptake by immune modulatory cells such as macrophages, DC, T, B, or mast cells [132, 134, 135]

2022;8:414 Marchi S, Guilbaud E, Tait SWG, Yamazaki T, Galluzzi L

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Moreover, not only oxidative and electrophilic reactions, but also other types of posttranslational modifications of Keap1, such as ubiquitination and phosphorylation, appear to be critical for regulating Nrf2 activity, which has been comprehensively discussed in a recent review ( Nrf2-Mediated Cardiac Protection Zhu et al