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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Bashshur R., Doarn C.R., Frenk J.M., Kvedar J.C., Woolliscroft J.O
During the first world war it was noticed that factory workers who were filling shells with DNP lost weight (some fatalities were also observed)
Upon engagement of PD-1 by its ligand PD-L1, the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) within the PD-1 cytoplasmic domain become phosphorylated
J Korean Soc Clin Toxicol 19(1):5963 Royer A, S.T
