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Thanacoody RH
We measured phase I and II cytochrome P450 enzymes, glutathione, reactive oxygen species, cytokines including Il6 , and pSTAT3 by reverse transcriptase quantitative PCR, colorimetric, immunohistochemistry analyses and Western blotting
Moreover, they highlight a compelling therapeutic opportunity: by disrupting chromatin-based plasticity, epigenetic drugs may dismantle the adaptive machinery that allows CSCs to survive and repopulate tumors
