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Description
This reaction is a rate-controlling step for the -oxidation of fatty acid (13)

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It is postulated that clinical symptoms, including CNS complications such as convulsion, coma and lethargy, may be triggered by the accumulation of metabolites and their acyl-CoA derivatives that disrupt intermediary metabolism [6669]
The suggestion that carnitine deficiency may lead to frailty through mitochondrial dysfunction (117) has been examined in one trial
