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It was found that renal tubular epithelial cells with the Atg5 gene knocked out failed to isolate the damaged lysosomes, which caused irreversible cell damage in mouse models of acute hyperuricemic nephritis 83
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Nat Med 23:850858 Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE (1995) Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
