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This dual action, increasing fat breakdown while simultaneously reducing new fat formation, has been observed in multiple rodent adipocyte models and provides a mechanistically distinct experimental profile compared to compounds that affect only one arm of fat metabolism

doi: 10.3389/fphar.2025.1643146 Received 18 June 2025 Revised 16 October 2025 Accepted 28 October 2025 Published 11 November 2025 Volume 16 - 2025 Edited by Karl Tsim, Hong Kong University of Science and Technology, Hong Kong, SAR China Reviewed by Qianghua Quan, Tsinghua University, China Jasmine Millman, Swisse Wellness Pty Ltd., Australia Updates Copyright 2025 Song, Sun, Yuan, Tang and Zheng

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The dietary food for the mice contained 52.22 g/g of aluminum, and most of the mice usually ate more than 4 g of food per day