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Glossary API apigenin APAP acetaminophen NAFLD non-alcoholic fatty liver disease ALD alcoholic liver disease HCC hepatocellular carcinoma Nrf2 nuclear factor erythroid 2-related factor 2 NF-B nuclear factor kappa-B PI3K phosphatidylinositide 3-kinase Akt protein kinase B mTOR mammalian target of rapamycin NLRP3 NOD-like receptor family pyrin domain containing 3 FXR farnesoid X receptor TGF-1 transforming growth factor-1 Smad3 mothers against decapentaplegic homolog 3 PPAR peroxisome proliferator-activated receptor alpha APAP acetaminophen NAPQI N-acetyl-p-benzoquinone imine GR glutathione reductase GSH glutathione MTX methotrexate ALT alanine aminotransferase AST aspartate aminotransferase CAT catalase ALP alkaline phosphatase GSH-Px glutathione peroxidase SOD superoxide dismutase TNF- tumor necrosis factor IL-1/6 interleukin-1/6 MDA malondialdehyde CYC cyclophosphamide

Pharmacokinetics and clinical pharmacology considerations of GalNAc3-conjugated antisense oligonucleotides

doi: 10.1007/978-3-642-13443-2_15

This step is rate-limiting in beta-oxidation and is a primary focus in fat utilization and energy substrate research