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Although we could not exclude the influence of different isolation procedures for each organ, along with the glutathione accumulation within TLS, these findings suggest that TLS in the kidney represent a unique microenvironment characterized by a dynamic equilibrium between oxidative stress and glutathione accumulation, which may play a pivotal role in regulating the formation of TLS and its function

After 24 h, the fluorescent intensity of the biofilm was determined at Ex 544 nm and Em 590 nm (Tecan infinite M1000 pro)

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Eur J Med Chem 2021;209:112891