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The parents were each heterozygous for one of the variants identified

SY: Data curation, Formal Analysis, Writing review & editing

Moreover, existing studies have shown that VEGF expression is closely related to oestrogen levels in osteoblasts, and oestradiol (E2) can upregulate VEGF expression through the activation of the PI3 K/Akt signalling pathway to promote new bone formation and bone repair [96]

10.1056/NEJMoa2001191 86 HuangC.WangY.LiX.RenL.ZhaoJ.HuY.et al
