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S-adenosylmethionine treatment of depression: a controlled clinical trial

Vitamin B-12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet difficulty walking (staggering, balance problems) anaemia a swollen, inflamed tongue difficulty thinking and reasoning (cognitive difficulties), or memory loss weakness fatigue While an experienced physician may notice the symptoms and be able to detect a vitamin B-12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition

MTHFR Mutation If you have an MTHFR gene mutation, your body struggles to process standard B12 and folate

Denials also arise when the diagnosis does not justify drug administration, when a more specific HCPCS code exists and should have been used, or when units billed do not match the documented dose