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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits

Additionally, individuals experiencing certain neurological symptoms or those with high levels of homocysteine, a risk factor for cardiovascular diseases, might find our B12 injections beneficial

At very high oral doses (54 mg), gastrointestinal side effects increased significantly

18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms