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Description
J Neurochem 64: 10881096
In CD8 + T cells from PWH, lower levels of SHMT2 impair mitochondrial function and reduce glutathione (GSH) levels, leading to higher ROS levels and triggering ageing processes

Storing a vial on its side or inverted keeps the solution in sustained contact with the rubber stopper, which pharmaceutical literature describes as a potential leachable-contamination pathway over extended periods

The high succinic is linked to complex II of the electron transport chain through an enzyme succinic acid dehydrogenase
