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Description
Inflammation is known to promote pigmentation such as in smokers melanosis and chronic oral inflammation from disease states
The released arachidonate then serves as the precursor for the synthesis of the biologically active eicosanoids, the prostaglandins (PG), thromboxanes (TX), and leukotrienes (LT)
[3] Howard Green, et al
In fact, clinical manifestations could result from reduced venous return and cardiac output
