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Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology, and prevention/therapy
The lethal concentration (LC 50 ) values derived from in vitro studies were used to design in vivo exposures, and real-time PCR analysis was conducted to compare gene expression patterns for selected genes ( cat , hsp70 , vtg1 , and cyp4 )
Perluigi et al
They also saw improvements in insulin sensitivity, body composition and muscle strength
