modifications to glutathione General scheme of metabolism (According Foyer and Noctor Glutathione in Mammalian Biology |

Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response and the induction of mitochondrial apoptosis

For example, guanine oxidation produces 8-oxo guanine (8-oxoG), which may lead to G-T or G-A transversions if unrepaired

doi: 10.1126/science.1209985 38 Martnez-VargasDValds-CruzAMagdaleno-MadrigalVMFernndez-MasRAlmazn-AlvaradoS

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