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The inhibition of UPS results in the perturbation of intracellular protein homeostasisfundamental for cell function and viabilityby the accumulation of poly-ubiquitinated proteins, which subsequently induces cellular stress and apoptosis

Future studies need to address how the NRF2-dependent network changes from a physiological (beneficial) to a pathological (adversary) condition that can provide insights into mechanisms of disease pathogenesis

Considering that multimeric IgM can efficiently bind viral antigens with repeated epitopes resulting in viral agglutination, stimulating the production of these IgM antibodies could be another weapon destined to combat lethal RNA viruses like SARS-CoV-2

Staining for type 1 fibers (MyHC-1+) revealed a predominant size reduction of type 2 muscle fibers ( Figure 2E)