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While DPP-IV is effective at cleaving proline bonds, it is an exopeptidase , meaning it can only snip amino acids from the external ends of the long protein chain
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In eyes where Im seeking to reduce IOP by more than 2 mm Hg, I am more likely to try Rocklatan first as it had a slight edge over Vyzulta compared to latanoprost alone in the MERCURY and VOYAGER trials, respectively
